Automation Open House | April 8, 2025

Presentations & Speakers

Pressure Reactions and High-Throughput Synthetic Experiments

Brandon Orzolek Scientific Director of the Automated Synthesis Facility Scripps Research

Jason Chen Executive Director of Core Facilities and Professor of Chemistry Scripps Research

Abstract: Scripps Research has a Big Kahuna for reaction screening and a Junior with OSR for pressure reactions and was a partner with Unchained Labs in developing small volume inserts for the OSR. The OSR at Scripps Research is among the busiest in the world. It supports diverse projects for different research groups, including hydrogenations, carbonylations, and aerobic oxidations. The chemistry and automation capabilities of the lab are currently being expanded to support accessible, high-throughput reaction screening through library building using the existing Unchained Labs ecosystem. With the new development in workflow and infrastructure, the lab seeks to harmonize fully- to semi-automated workflows to enable synthetic chemistry in the academic environment.



Driving CMC Innovation with Automation: Insights from Genentech

Adam Childs Scientist III Genentech

Abstract: Automation has become a cornerstone of Chemistry, Manufacturing, and Controls (CMC) development, propelled by continuous advancements in robotics and analytical instrumentation. Robust workflows powered by automation can greatly reduce cycle times across various stages of CMC, enabling the efficient and timely delivery of life-saving medicines to patients. This work highlights how diverse automation workflows, developed using cutting-edge robotic platforms, are leveraged to accelerate the process and formulation development of small molecule drugs as well as emerging new modalities. These workflows range from multiple process workflows, including reaction, solubility, salt and polymorph, as well as scavenger screening to formulation screening. Additionally, insights into future trends within the field will be discussed as well. Overall, we believe that embracing automation not only increases efficiency and productivity but also holds the potential to revolutionize modern pharmaceutical CMC development.



Self-Driving HTE for Synthetic Molecules Process Development

Adrian Ramirez Galilea Associate Director, HTE & Automation Takeda



Accelerating High-Throughput Research with the Big Kahuna

Jordan Mowbray Senior R&D Technologist The Dow Chemical Company

Abstract: High-Throughput research is a cornerstone for accelerating innovation at Dow and is integral for catalyst discovery and product development. Using the Big Kahuna Reactor, both olefin and epoxide polymerization chemistries have been validated. This flexibility highlights the ease in which external peripherals that are necessary to run these diverse reactions can be incorporated. The Big Kahuna also enables collection of high quality, reproducible data both from a process and polymer product standpoint increasing project efficiency and productivity. The reactor provides many advantages over its predecessor, the parallel pressure reactor (PPR). These advantages include the ability to run at a range of reaction volumes, including larger ones that may be necessary for certain downstream application testing and smaller ones when raw materials are precious. This talk will showcase how the Big Kahuna Reactor can be used for catalyst screening and material property studies at Dow through selected examples.



More details and presentations to come!

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Agenda

Presentations & Speakers

Agenda

	Registration/Breakfast Presentations on Automation in Chemistry & Biologics Lunch Instrument Demos Happy Hour

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